Storage lesion describes the degradation of the RBC involving the loss of what?

Storage lesion refers to the changes that red blood cells (RBCs) undergo when they are stored before transfusion. This condition primarily involves the loss of membrane plasticity, which is critical for the optimal functionality and durability of RBCs.

As RBCs are stored, their membranes can become damaged and lose flexibility due to a variety of factors, including the accumulation of metabolites, the process of refrigeration, and the degree of storage time. Loss of membrane plasticity means the cells become less capable of deforming, which is essential for navigating through the narrow capillaries and for efficient gas exchange. Such changes can lead to increased hemolysis and reduced survival of the transfused RBCs in the recipient's circulation.

In the context of the choices provided, while hemoglobin, glucose, and electrolytes play roles in RBC function and viability, the specific aspect of storage lesions that is most directly impactful on RBC longevity and functionality relates to the alteration of the RBC membrane structure, thereby impacting its plasticity. The loss of plasticity can ultimately lead to compromised blood transfusion outcomes and is a focal point when considering optimal storage conditions and the timing of blood product use.