What is the maximum rate of Tissue Plasminogen Activator (tPA) for a patient with severe frostbite on two extremities?

The correct answer is based on the established protocols for administering Tissue Plasminogen Activator (tPA) in cases of severe frostbite. When treating frostbite, tPA is used to enhance blood flow and facilitate the revascularization of affected tissues. The guideline specifies that the rate of tPA administration should be calculated per extremity involved.

In this scenario, a total dose of 0.5 mg per hour is allocated for each extremity affected by severe frostbite. Since the patient has frostbite on two extremities, the maximum infusion rate aligns with the established standard of care that allows for optimal therapeutic effects while minimizing the risk of complications. This careful calculation supports effective treatment and acknowledges the vulnerabilities in patients experiencing severe frostbite.

The rationale aligns with treatment recommendations to ensure proper dosage that is safe and maximizes efficacy for each extremity, underscoring the importance of tailored dosing in critical care scenarios. Other choices would either miscalculate the total rate for the number of affected areas or misapply the infusion rates according to clinical guidance.