What is the most commonly available antidote for cyanide poisoning?

Hydroxocobalamin, commonly referred to as Cyanokit, is recognized as the most commonly available antidote for cyanide poisoning. It works by binding to cyanide ions to form a stable complex that is excreted by the kidneys, effectively reducing the toxicity of cyanide in the bloodstream. This antidote is particularly valuable in emergency situations due to its rapid administration and effectiveness in treating cyanide toxicity, which can arise from various sources, such as smoke inhalation in fires or chemical exposures.

Sodium thiosulfate is also used as a treatment for cyanide poisoning and can be effective, but it is typically used in conjunction with hydroxocobalamin, especially in cases of severe poisoning. Activated charcoal is not an antidote but is sometimes administered in cases of oral poisoning to limit absorption, and calcium gluconate is primarily used for treating calcium channel blocker or magnesium toxicity, not cyanide exposure. Hence, hydroxocobalamin stands out as the preferred and most readily available antidote specifically formulated to counteract the effects of cyanide poisoning.