Which group of donors is typically excluded from donating blood to reduce the risk of TRALI?

The correct answer is previously pregnant female donors, as they are typically excluded from donating blood to reduce the risk of Transfusion-Related Acute Lung Injury (TRALI). This decision is based on research that indicates that female donors who have been previously pregnant are more likely to have antibodies against HLA (human leukocyte antigen) which can react with the recipient’s immune system during a blood transfusion. These antibodies can lead to the severe pulmonary complications associated with TRALI, making it a significant concern in transfusion medicine.

In contrast, while all female donors might seem like a safe choice to eliminate risk, this would unnecessarily limit the donor pool and isn't a practical solution. Male donors, on the other hand, are typically not at risk since they usually do not develop these antibodies due to not being pregnant. Non-DAB positive donors do not directly relate to the TRALI risk, as this term encompasses a different aspect of blood typing and compatibility. Therefore, the decision to exclude previously pregnant female donors is a targeted strategy aimed at minimizing the risk of TRALI while still maintaining a diverse and sufficient blood supply.